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BJ163192
BIO-X

JNJ 10198409 NEW

Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.

Technical Data

CAS No: 627512-69-0
Synonyms: N-​(3-​Fluorophenyl)​-​2,​4-​dihydro-​6,​7-​dimethoxy-indeno[1,​2-​c]​pyrazol-​3-​amine; RWJ 540973
Product Code: BJ163192
MDL No: MFCD11045292
Chemical Formula: C18H16FN3O2
Molecular Weight: 325.34

References


  • Grinshtein et al (2011). Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Research 71:1385-95.
  • Ho et al (2005). 6,7-Dimethoxy-2,4-dihydroinden[o 1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. Journal of Medicinal Chemistry 48:8163-73.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
627512-69-0
Synonyms:
N-​(3-​Fluorophenyl)​-​2,​4-​dihydro-​6,​7-​dimethoxy-indeno[1,​2-​c]​pyrazol-​3-​amine
RWJ 540973
MDL No:
MFCD11045292
Chemical Formula:
Molecular Weight:
325.34
Product Structure
References:
1. Grinshtein et al (2011). Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells. Cancer Research 71:1385-95.
2. Ho et al (2005). 6,7-Dimethoxy-2,4-dihydroinden[o 1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. Journal of Medicinal Chemistry 48:8163-73.
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