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BS168651
BIO-X

Squarunkin A NEW

Selective inhibitor of the interaction between the UNC119 chaperone and its cargo. Squarunkin A inhibits activation of Src kinase by interrupting the interaction between the myristoylated peptide at the N-terminus of the Src kinase and UNC119A chaperone (IC50 = 10 nM). Squarunkin A impairs the UNC119-mediated enrichment of plasma membrane with non-receptor protein tyrosine kinase Src, resulting in the decrease in Src autophosphorylation and decreased oncogenic Src signalling.

Technical Data

CAS No: 2101958-02-3
Synonyms: 4-[[3,4-Dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-1-piperidinecarboxylic acid, ethyl ester
Product Code: BS168651
Chemical Formula: C25H32F3N5O4
Molecular Weight: 523.55

References


  • Garivet et al (2019). Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells. Cell Chemical Biology 26(6):842-851.
  • Stephen et al (2018). The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Developmental Cell 47(1):122–132.
  • Mejuch et al (2017). The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK. Angewandte Chemie International Edition 56(22):6181-6186.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2101958-02-3
Synonyms:
4-[[3,4-Dioxo-2-[[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]amino]-1-cyclobuten-1-yl]amino]-1-piperidinecarboxylic acid, ethyl ester
Chemical Formula:
Molecular Weight:
523.55
Product Structure
References:
1. Garivet et al (2019). Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells. Cell Chemical Biology 26(6):842-851.
2. Stephen et al (2018). The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK. Developmental Cell 47(1):122–132.
3. Mejuch et al (2017). The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK. Angewandte Chemie International Edition 56(22):6181-6186.
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