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BU167832
BIO-X

UNC 4203 NEW

Potent and specific inhibitor of the tyrosine protein kinase Mer precursor (MERTK) with 38-fold selectivity over the FMS-like protein kinase FLT3. UNC 4203 inhibits MERTK with an IC50 value of 2.4 nM and shows favourable pharmacokinetic properties. In vivo experiments in mice showed that UNC 4203 dramatically decreased the phosphorylation of MERTK in bone marrow leukemia cells.

Technical Data

CAS No: 1818234-19-3
Product Code: BU167832
MDL No: MFCD31735120
Chemical Formula: C30H44N6O
Molecular Weight: 504.71

References


  • Zhao et al (2018). Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. Jornal of Medicinal Chemistry 61:10242−10254.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1818234-19-3
MDL No:
MFCD31735120
Chemical Formula:
Molecular Weight:
504.71
Product Structure
References:
1. Zhao et al (2018). Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. Jornal of Medicinal Chemistry 61:10242−10254.
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