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BT162782

TD 114-2 - Bio-X NEW

Potent and selective GSK3-β inhibitor, with IC50 value of 48 nM. Increases Nanog expression and regulates self-renewal in murine embryonic stem cells (ESCs). Induces reprograming of induced pluripotent stem cells (iPSCs) to derive cells from specific lineages.

Technical Data

CAS No: 436866-52-3
Synonyms: 6,​7,​9,​10,​12,​13,​15,​16,​18,​19-Decahydro-5,​29:20,​25-​dimetheno-​26H-​dibenzo[n,​t]​pyrrolo[3,​4-​q]​[1,​4,​7,​10,​13,​22]​tetraoxadiazacyclote​tracosine-​26,​28(27H)​-​dione
Product Code: BT162782
Chemical Formula: C30H31N3O6
Molecular Weight: 529.58

Literature


  • Kuo GH et al (2003). Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors. J Med Chem 46(19):4021-31.
  • Storm MP et al (2007). Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem 282(9):6265-73.
  • Li X et al (2017). Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell 21(2):264-273.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

TD 114-2 - Bio-X

CAS No:
436866-52-3
Synonyms:
6,​7,​9,​10,​12,​13,​15,​16,​18,​19-Decahydro-5,​29:20,​25-​dimetheno-​26H-​dibenzo[n,​t]​pyrrolo[3,​4-​q]​[1,​4,​7,​10,​13,​22]​tetraoxadiazacyclote​tracosine-​26,​28(27H)​-​dione
Chemical Formula:
Molecular Weight:
529.58
Product Structure
References:
1. Kuo GH et al (2003). Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors. J Med Chem 46(19):4021-31.
2. Storm MP et al (2007). Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells. J Biol Chem 282(9):6265-73.
3. Li X et al (2017). Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell 21(2):264-273.
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