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AG167808
BIO-X

GS 441524 NEW

Nucleoside analog with antiviral activity against zoonotic feline infectious peritonitis virus (FIPV) and severe acute respiratory syndrome (SARS) virus from Coronaviridae family. The compound is a pro-drug and undergoes intracellular phosphorylation resulting in the active triphosphate metabolite. The triphosphorylated GS 441524 analog competes with natural nucleoside triphosphates and interferes with viral RNA synthesis. In previous studies it was tested in vitro as well as in experimental animals and showed good safety profile.

Technical Data

CAS No: 1191237-69-0
Synonyms: 2-​C-​(4-​Aminopyrrolo[2,​1-​f]​[1,​2,​4]​triazin-​7-​yl)​-​2,​5-​anhydro-D-​altrononitrile
Product Code: AG167808
Chemical Formula: C12H13N5O4
Molecular Weight: 291.26

References


  • Pedersen et al (2019). Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. Journal of Feline Medicine and Surgery 1-11.
  • Murphy et al (2018). The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Veterinary Microbiology 219:226-233.
  • Cho et al (2012). Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorganic Medicinal Chemistry Letters 22:2705-2707.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1191237-69-0
Synonyms:
2-​C-​(4-​Aminopyrrolo[2,​1-​f]​[1,​2,​4]​triazin-​7-​yl)​-​2,​5-​anhydro-D-​altrononitrile
Chemical Formula:
Molecular Weight:
291.26
Product Structure
References:
1. Pedersen et al (2019). Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. Journal of Feline Medicine and Surgery 1-11.
2. Murphy et al (2018). The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Veterinary Microbiology 219:226-233.
3. Cho et al (2012). Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorganic Medicinal Chemistry Letters 22:2705-2707.
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