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BB170419
BIO-X

BT 18

Activator of RET signalling cascade and a derivative of a GFL mimetic compound BT 13. Molecular docking calculations and molecular dynamics simulations were performed in GDNF−GFRα1−RetA complex and showed that BT 18 binds to the allosteric site in GFRα1 as well as RetA surface interfacing GFRα1.

Technical Data

CAS No: 924811-53-0
Synonyms: ([4-[5- [(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]-2- methoxyphenyl]piperazin-1-yl]-[4-fluoro-2-(trifluoromethyl)- phenyl]methanone); BT18
Product Code: BB170419
Chemical Formula: C30H31F4N3O6S
Molecular Weight: 637.64

References


  • Ivanova et al (2018). Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega 3:11407−11414.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
924811-53-0
Synonyms:
([4-[5- [(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]-2- methoxyphenyl]piperazin-1-yl]-[4-fluoro-2-(trifluoromethyl)- phenyl]methanone)
BT18
Chemical Formula:
Molecular Weight:
637.64
Product Structure
References:
1. Ivanova et al (2018). Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega 3:11407−11414.
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