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FA17244

Agomelatine

A competitive antagonist of 5-HT2B and 5-HT2C serotonin receptors. A melatonin analog and an agonist of melatonin receptors MT1 and MT2. Has potential as an anti-depressant agent.

Technical Data

CAS No: 138112-76-2
Synonyms: N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide; S20098
Product Code: FA17244
MDL No: MFCD00916659
Chemical Formula: C15H17NO2
Molecular Weight: 243.30

References


  • Yous S et al (1992). Novel naphthalenic ligands with high affinity for the melatonin receptor. J Med Chem 35(8):1484-6.
  • Millan MJ et al (2003). The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306(3):954-64.
  • den Boer JA et al (2006). Clinical efficacy of agomelatine in depression: the evidence. Int Clin Psychopharmacol 21 Suppl 1:S21-4.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
138112-76-2
Synonyms:
N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide
S20098
MDL No:
MFCD00916659
Chemical Formula:
Molecular Weight:
243.30
Product Structure
References:
1. Yous S et al (1992). Novel naphthalenic ligands with high affinity for the melatonin receptor. J Med Chem 35(8):1484-6.
2. Millan MJ et al (2003). The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306(3):954-64.
3. den Boer JA et al (2006). Clinical efficacy of agomelatine in depression: the evidence. Int Clin Psychopharmacol 21 Suppl 1:S21-4.
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