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FB159390

BAY 73-6691 - Bio-X

Potent inhibitor of phosphodiesterase type 9 (PDE9), tested in human and murine in vitro assays (IC50 values: 55 nM and 100 nM, respectively). BAY 73-6691 induces long-term potentiation and improves memory in rodents. BAY 73-6691 has been studied as a potential therapy for Alzheimer’s disease. 

Technical Data

CAS No: 794568-92-6
Synonyms: 1-​(2-​Chlorophenyl)​-​6-​[(2R)​-​3,​3,​3-​trifluoro-​2-​methylpropyl]​-​2H-​pyrazolo[3,​4-​d]​pyrimidin-​4-​one
Product Code: FB159390
Chemical Formula: C15H12ClF3N4O
Molecular Weight: 356.73

Literature


  • Wunder F et al, 2005.Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line. Mol Pharmacol. 68(6):1775-81.
  • Li J et al, 2016.Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease. Brain Res 1642:327-335.
  • van der Staay et al, 2008.The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology 55(5):908-18.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

BAY 73-6691 - Bio-X

CAS No:
794568-92-6
Synonyms:
1-​(2-​Chlorophenyl)​-​6-​[(2R)​-​3,​3,​3-​trifluoro-​2-​methylpropyl]​-​2H-​pyrazolo[3,​4-​d]​pyrimidin-​4-​one
Chemical Formula:
Molecular Weight:
356.73
Product Structure
References:
1. Wunder F et al, 2005.Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line. Mol Pharmacol. 68(6):1775-81.
2. Li J et al, 2016.Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease. Brain Res 1642:327-335.
3. van der Staay et al, 2008.The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology 55(5):908-18.
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