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BU140504

URB 597 - Bio-X NEW

A selective and potent inhibitor of fatty-acid amide hydrolase, with IC50 values of 5 nM and 3 nM in rat brain and human liver respectively. Anti-inflammatory and anti-hypertensive effects demonstrated in rat models of hypertension. Activation of cannabinoid receptors by URB 596 in inflammatory pain model results in anti-allodynic and anti-hyperalgesic activity.

Technical Data

CAS No: 546141-08-6
Synonyms: 3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Product Code: BU140504
MDL No: MFCD05863934
Chemical Formula: C20H22N2O3
Molecular Weight: 338.40

References


  • Jayamanne A et al (2006). Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol 147(3):281-8.
  • Piomelli D et al (2006). Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 12(1):21-38.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

URB 597 - Bio-X

CAS No:
546141-08-6
Synonyms:
3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate
MDL No:
MFCD05863934
Chemical Formula:
Molecular Weight:
338.40
Product Structure
References:
1. Jayamanne A et al (2006). Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br J Pharmacol 147(3):281-8.
2. Piomelli D et al (2006). Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 12(1):21-38.
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