Dodecyl maltoside (DDM) is a non-ionic detergent that consists of a hydrophilic maltose head and a hydrophobic long chain alkyl tail. It has a relatively low critical micelle concentration of 0.17 mM and is considered a gentle but powerful detergent. DDM is often the best tool for solubilizing/ crystallizing membrane proteins. Membrane proteins usually have alpha-helical structures that are easily destroyed when the protein is released from its membrane environment. DDM can often preserve these structures during the solubilization. In addition, membrane proteins can often be renatured when isolated with DDM.