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FB146398

Lifitegrast - Bio-X

Inhibits binding of lymphocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1) surface integrins. The activity of lifitegrast on these proteins at the ocular surface leads to suppressed T-cell mediated inflammatory response involved in dry eye disease. This compound also has therapeutic potential for contact lens-related corneal infiltrates. 

Technical Data

CAS No: 1025967-78-5
Synonyms: N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine; SAR 1118
Product Code: FB146398
Chemical Formula: C29H24Cl2N2O7S
Molecular Weight: 615.48

Literature


  • Sun Y et al (2013). Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther 29(4):395-402.
  • Perez VL et al (2016). Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf 14(2):207-15.
  • Paton DM (2016). Lifitegrast: First LFA-1/ICAM-1 antagonist for treatment of dry eye disease. Drugs Today (Barc) 52(9):485-493.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

Lifitegrast - Bio-X

CAS No:
1025967-78-5
Synonyms:
N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-L-phenylalanine
SAR 1118
Chemical Formula:
Molecular Weight:
615.48
Product Structure
References:
1. Sun Y et al (2013). Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther 29(4):395-402.
2. Perez VL et al (2016). Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf 14(2):207-15.
3. Paton DM (2016). Lifitegrast: First LFA-1/ICAM-1 antagonist for treatment of dry eye disease. Drugs Today (Barc) 52(9):485-493.
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