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FB64960
BIO-X

BMS 754807

A reversible inhibitor of IGF-1R kinase and insulin receptor. Has anti-growth effects in mesenchymal, epithelial and hematopoietic tumor types. Synergistic with other cytotoxic, hormonal and targeted anti-cancer therapy.

Technical Data

CAS No: 1001350-96-4
Product Code: FB64960
MDL No: MFCD18633202
Chemical Formula: C23H24FN9O
Molecular Weight: 461.50

References


  • Carboni JM et al (2009). BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 8(12):3341-9.
  • Wittman MD et al (2009). Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 52(23):7360-3.
  • Scagliotti GV and Novello S (2012). The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors. Cancer Treat Rev 38(4):292-302.

Solubility

Stability

Further Information


Datasheets


CAS No:
1001350-96-4
MDL No:
MFCD18633202
Chemical Formula:
Molecular Weight:
461.50
Product Structure
References:
1. Carboni JM et al (2009). BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 8(12):3341-9.
2. Wittman MD et al (2009). Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 52(23):7360-3.
3. Scagliotti GV and Novello S (2012). The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors. Cancer Treat Rev 38(4):292-302.

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