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FA145501
BIO-X

AR-R 17779 hydrochloride

AR-R 17779 is a selective agonist for α7 nicotinic acetylcholine receptors (nAChRs) (Ki value = 190 nM for rat α7 receptor). This compound has use as a tool to study the function of α7 nicotinic receptors. One such study revealed a role for α7 nicotinic receptors in nicotine-mediated excitatory effects on hippocampal learning and memory. AR-R17779 reduces formation of atherosclerotic plaques and abdominal aortic aneurysms in apolipoprotein E-deficient mice. 

Technical Data

CAS No: 178419-42-6
Synonyms: (3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
Product Code: FA145501
MDL No: MFCD20926337
Chemical Formula: C9H14N2O2·HCl
Molecular Weight: 218.68

References


  • Mullen G et al (2000). (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem 43(22):4045-50.
  • Huang LT et al (2010). Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br J Pharmacol 159(3):554-65.
  • Hashimoto T et al (2014). Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice. Vascul Pharmacol 61(2-3):49-55.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

AR-R 17779 hydrochloride - Bio-X

CAS No:
178419-42-6
Synonyms:
(3S)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidine]-2'-one hydrochloride
MDL No:
MFCD20926337
Chemical Formula:
Molecular Weight:
218.68
Product Structure
References:
1. Mullen G et al (2000). (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem 43(22):4045-50.
2. Huang LT et al (2010). Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br J Pharmacol 159(3):554-65.
3. Hashimoto T et al (2014). Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice. Vascul Pharmacol 61(2-3):49-55.
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