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FA64945
BIO-X

Asunaprevir

A competitive inhibitor of HCV NS3/4A protease that blocks viral replication. Efficacious in treating HCV-infected patients in combination with daclatasvir. Asunaprevir-resistant replicons are sensitive to NS5A replication complex inhibitor, suggesting potential combination therapy.

Technical Data

CAS No: 630420-16-5
Product Code: FA64945
MDL No: MFCD27987900
Chemical Formula: C35H46ClN5O9S
Molecular Weight: 748.29

References


  • McPhee F et al (2012). Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032). Antimicrob Agents Chemother 56(10):5387-96.
  • McPhee F et al (2012). Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir. Antimicrob Agents Chemother 56(7):3670-81.
  • Scola PM et al (2014). The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. J Med Chem 57(5):1730-52.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
630420-16-5
MDL No:
MFCD27987900
Chemical Formula:
Molecular Weight:
748.29
Product Structure
References:
1. McPhee F et al (2012). Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032). Antimicrob Agents Chemother 56(10):5387-96.
2. McPhee F et al (2012). Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir. Antimicrob Agents Chemother 56(7):3670-81.
3. Scola PM et al (2014). The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection. J Med Chem 57(5):1730-52.
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