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BU167099

UNC 2881 - Bio-X

Inhibits Mer receptor tyrosine kinase (IC50 = 4.3 nM). Selective over Axl (84-fold) and Tyro3 (58-fold). UNC 2881 inhibits phosphorylation of Mer kinase in 697 B-ALL cells (IC50 = 22nM). Inhibits EGF-induced activation of a chimeric enzyme, composed of EGFR fused with Mer. Blocks collagen-mediated platelet aggregation, implying the potential of this compound for treating thrombosis.

Technical Data

CAS No: 1493764-08-1
Product Code: BU167099
Chemical Formula: C25H33N7O2
Molecular Weight: 463.58

References


  • Zhang W et al (2013). Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem 56(23):9693-700.

Solubility

Stability

Further Information


Datasheets


UNC 2881 - Bio-X

CAS No:
1493764-08-1
Chemical Formula:
Molecular Weight:
463.58
Product Structure
References:
1. Zhang W et al (2013). Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem 56(23):9693-700.

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