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BA167526
BIO-X

ASP 3662

Inhibits 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an enzyme required for the intracellular regeneration of glucocorticoids in the CNS. ASP 3662 is selective over 11β-HSD2 and is CNS-penetrant. Reduces chronic pain by maintaining high levels of inactive glucocorticoids and thus demonstrates its anti-nociceptive and analgesic protperties. A potential candidate for the treatment of neuropathic and dysfunctional pain.

Technical Data

CAS No: 1204178-50-6
Product Code: BA167526
MDL No: MFCD31735113
Chemical Formula: C19H16ClF3N4O2
Molecular Weight: 424.80

References


  • Kiso T et al (2018). Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain. Br J Pharmacol 175(19):3784-3796.

Solubility

Stability

Further Information


Datasheets


CAS No:
1204178-50-6
MDL No:
MFCD31735113
Chemical Formula:
Molecular Weight:
424.80
Product Structure
References:
1. Kiso T et al (2018). Analgesic effects of ASP3662, a novel 11β-hydroxysteroid dehydrogenase 1 inhibitor, in rat models of neuropathic and dysfunctional pain. Br J Pharmacol 175(19):3784-3796.

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