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BC165637
BIO-X

CP 724714 NEW

Inhibitor of erbB2 (IC50 = 3 nM) and EGFR kinase (IC50 = 6.4 nM) with anti-proliferative effects. It inhibits erbB2 receptor autophosphorylation and induces G1 cell cycle block. The CP 724714 treatment induces reduction of downstream erbB2 receptor tyrosine kinase signalling, tumor cell apoptosis, release of caspase 3 and regression of tumors in in vivo and in vitro models.

Technical Data

CAS No: 383432-38-0,537705-08-1
Synonyms: (E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate
Product Code: BC165637
MDL No: MFCD15144738
Chemical Formula: C27H27N5O3
Molecular Weight: 469.54

Literature

References
  • Jani et al., 2007. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67(20):9887-93.

Solubility

Stability

Datasheets


CP 724714

CAS No:
383432-38-0,537705-08-1
Synonyms:
(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate
MDL No:
MFCD15144738
Chemical Formula:
Molecular Weight:
469.54
Product Structure
References:
1. Jani et al., 2007. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res. 67(20):9887-93.

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