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OO35336

GD1a-Oligosaccharide

Oligosaccharide moiety from the disialylated glycosphingolipid GD1a of a-series, which is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. It plays a role in viral infection since it is a receptor for viral glycoproteins in rotavirus and paramyxovirus 1. The hexasaccharide GD1a moiety was also found on a glycoprotein that acts as a receptor for adenovirus type 37. GD1a ganglioside also interacts with botulinum neurotoxin (BoNT) and is crucial for its entry into cells.

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Technical Data

CAS No: 71494-27-4,1627679-86-0
Synonyms: GD1aSaccharide
Product Code: OO35336
Chemical Formula: C48H79N3O37
Molecular Weight: 1290.14

References


  • Yu et al (2012). Functional roles of gangliosides in neurodevelopment: An overview of recent advances. Neurochemistry Research 37:1230–1244.
  • Nilsson et al (2011). The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nature Medicine 17:105-109.
  • Schnaar (2010). Brain gangliosides in axon–myelin stability and axon regeneration. FEBS Letters 584:1873-3468.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
71494-27-4,1627679-86-0
Synonyms:
GD1aSaccharide
Chemical Formula:
Molecular Weight:
1290.14
Product Structure
References:
1. Yu et al (2012). Functional roles of gangliosides in neurodevelopment: An overview of recent advances. Neurochemistry Research 37:1230–1244.
2. Nilsson et al (2011). The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nature Medicine 17:105-109.
3. Schnaar (2010). Brain gangliosides in axon–myelin stability and axon regeneration. FEBS Letters 584:1873-3468.
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