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OG16188

GM3-Ganglioside sodium

Monosialylated sphingolipid of a-series. Major ganglioside component in neuronal progenitor cells, where it stimulates β1-integrin expression and promotes self-renewal and cell proliferation. Interacts with insulin receptor, negatively regulates insulin signalling, and promotes insulin resistance. GM3 interacts also with EGFR and inhibits receptor auto-phosphorylation and subsequent activation.

Technical Data

CAS No: 54827-14-4
Synonyms: aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer
Product Code: OG16188
MDL No: MFCD00131139
Chemical Formula: C59H111N3O21·xNa
Molecular Weight: 1180.52 (free acid basis)

References


  • Suzuki et al (2010). Involvement of 1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells. Journal of Biological Chemistry 285:18443–18451.
  • Veillon et al (2015). Identification of ganglioside GM3 molecular species in human serum associated with risk factors of metabolic syndrome. PLoS ONE 10:e0129645.
  • Bremer et al (1986). Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. Journal of Biolical Chemistry 261:2434–2440.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
54827-14-4
Synonyms:
aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer
MDL No:
MFCD00131139
Chemical Formula:
Molecular Weight:
1180.52 (free acid basis)
Product Structure
References:
1. Suzuki et al (2010). Involvement of 1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells. Journal of Biological Chemistry 285:18443–18451.
2. Veillon et al (2015). Identification of ganglioside GM3 molecular species in human serum associated with risk factors of metabolic syndrome. PLoS ONE 10:e0129645.
3. Bremer et al (1986). Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. Journal of Biolical Chemistry 261:2434–2440.
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