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FA07133

Adefovir

An acyclic phosphonate nucleotide analog of dAMP. Has anti-viral activity against HIV-1 and HBV by inhibiting reverse transcriptase and polymerase activity, respectively. Demonstrates improved antiviral activity when combined with other HBV drugs.

Technical Data

CAS No: 106941-25-7
Synonyms: 9-[2-(Phosphonomethoxy)ethyl]adenine; [2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonic acid; PMEA
Product Code: FA07133
MDL No: MFCD00866943
Chemical Formula: C8H12N5O4P
Molecular Weight: 273.19

Literature

References
  • Cundy KC et al (1995). Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 39(11):2401-5.
  • Delmas J et al (2002). Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrob Agents Chemother 46(2):425-33.
  • Delaney WE 4th et al (2004). Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrob Agents Chemother 48(10):3702-10.

Solubility

Stability

Datasheets

Specification: View
MSDS: View

Adefovir

CAS No:
106941-25-7
Synonyms:
9-[2-(Phosphonomethoxy)ethyl]adenine
[2-(6-Amino-9H-purin-9-yl)ethoxy]methylphosphonic acid
PMEA
MDL No:
MFCD00866943
Chemical Formula:
Molecular Weight:
273.19
Product Structure
References:
1. Cundy KC et al (1995). Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother. 39(11):2401-5.
2. Delmas J et al (2002). Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro. Antimicrob Agents Chemother 46(2):425-33.
3. Delaney WE 4th et al (2004). Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrob Agents Chemother 48(10):3702-10.
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