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BJ165317

JNJ 38877605 - Bio-X NEW

Potent inhibitor of c-Met catalytic activity. Selective over other tyrosine and serine-threonine kinases (600-fold selectivity). Ability to block constitutive or HGF-stimulated phosphorylation of c-Met demonstrated in vitro. JNJ 38877605 reduces radiation-induced invasion, apoptosis and proliferation of cancer cells in vitro.

Technical Data

CAS No: 943540-75-8
Synonyms: 6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Product Code: BJ165317
Chemical Formula: C19H13F2N7
Molecular Weight: 377.35

References


  • Perera T et al (2008). JNJ-38877605: a selective Met kinase inhibitor inducing regression of Met-driven tumor models. AACR 68(9):4837.
  • De Bacco F et al (2011). Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst 103(8):645-61.
  • Li W et al (2015). Effectiveness of inhibitor rapamycin, saracatinib, linsitinib and JNJ-38877605 against human prostate cancer cells. Int J Clin Exp Med 8(4):6563–6567.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

JNJ 38877605 - Bio-X

CAS No:
943540-75-8
Synonyms:
6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Chemical Formula:
Molecular Weight:
377.35
Product Structure
References:
1. Perera T et al (2008). JNJ-38877605: a selective Met kinase inhibitor inducing regression of Met-driven tumor models. AACR 68(9):4837.
2. De Bacco F et al (2011). Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst 103(8):645-61.
3. Li W et al (2015). Effectiveness of inhibitor rapamycin, saracatinib, linsitinib and JNJ-38877605 against human prostate cancer cells. Int J Clin Exp Med 8(4):6563–6567.
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