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BG166668

GSK 2636771 - Bio-X

Selective inhibitor of phosphoinositide 3 kinase beta subunit (PI3Kβ) with IC50 = 5.2 nM. This compound competes with ATP for binding to the beta subunit of PI3K complex and inhibits the growth of phosphatase and tensin homolog (PTEN)-deficient tumor cells. Unlike the pan-PI3K inhibitors, GSK 2636771 does not cause side effects such as skin rash, hyperglycemia and diarrhea.

Technical Data

CAS No: 1421958-41-9
Product Code: BG166668
Chemical Formula: C22H22F3N3O3
Molecular Weight: 433.42

Literature


  • Mateo J et al. (2017). A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res 23(19):5981-5992.

Solubility

Stability

Further Information


Datasheets


GSK 2636771 - Bio-X

CAS No:
1421958-41-9
Chemical Formula:
Molecular Weight:
433.42
Product Structure
References:
1. Mateo J et al. (2017). A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res 23(19):5981-5992.

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