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AT45107

Trichostatin A

Histone deacetylase inhibitor; anti-fungal; primordial germ cell reprogramming

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A potent inhibitor of histone deacetylases (HDACs) of class I and II with anti-tumoral activity. The compound blocks HDAC catalytic activity by chelating zinc ion in the enzyme’s active site. Extensively used in research as epigenetic modifier able to block cell growth and downregulate proliferation-associated factors. It has also been reported that trichostatin A induces apoptosis via a histone-modification independent mechanism in oral squamous cell carcinoma cell lines. Initially discovered as anti-fungal compound from Streptomyces hygroscopicus for the control of fungal infections caused by the genus Trichophyton.

Technical Data

CAS No: 58880-19-6
Product Code: AT45107
MDL No: MFCD03848392
Chemical Formula: C17H22N2O3
Molecular Weight: 302.37

References


  • Furumai et al., 2001. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. PNAS 98(1):87-92.
  • Jang et al., 2018. Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. J Cancer Res Ther S576-S582.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

Trichostatin A

CAS No:
58880-19-6
MDL No:
MFCD03848392
Chemical Formula:
Molecular Weight:
302.37
Product Structure
References:
1. Furumai et al., 2001. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. PNAS 98(1):87-92.
2. Jang et al., 2018. Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. J Cancer Res Ther S576-S582.
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