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BK167284
BIO-X

KRH 3955

A potent antagonist of chemokine receptors CXCR4, inhibiting both the binding of SDF-1α and Ca2+ signaling. KRH 3955 also potently inhibits the replication of X4 HIV-1, including recombinant X4 HIV-1 with mutations conferring resistance to NRTIs, NNRTIs, PIs and T20. KRH 3955 may have therapeutic potential in diseases involving CXCR4-SDF-1 interaction, such as cancer, leukaemia, rheumatoid arthritis and pulmonary fibrosis. 

Technical Data

CAS No: 1097732-62-1
Product Code: BK167284
Chemical Formula: C28H45N7·3C4H6O6
Molecular Weight: 929.96

References


  • Murakami T et al (2009). The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. Antimicrob Agents Chemother 53(7):2940-8.

Solubility

Stability

Further Information


Datasheets


KRH 3955 - Bio-X

CAS No:
1097732-62-1
Chemical Formula:
Molecular Weight:
929.96
Product Structure
References:
1. Murakami T et al (2009). The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. Antimicrob Agents Chemother 53(7):2940-8.

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