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FC139019

SCH 23390 HCl - Bio-X NEW

Antagonist of D1-like dopamine receptor subtypes, D1 and D5 (Ki values 0.2 and 0.3 nM respectively). Agonist of serotonin receptors 5-HT1C and 5-HT2C (Ki values 6.3 nM and 9.3 nM respectively). Used to study the topography of D1 receptors in humans and animals. Reduces seizures in response to chemoconvulsants and has also been studied in other neurological disorders.

Technical Data

CAS No: 125941-87-9
Synonyms: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride; (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-Benzazepin-7-ol hydrochloride(9CI)
Product Code: FC139019
Chemical Formula: C17H18ClNO·HCl
Molecular Weight: 324.24

References


  • Bourne JA (2001). SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev 7(4):399-414.
  • Millan MJ et al (2001). The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl) 156(1):58-62.
  • Cadet JL et al (2010). Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targets 9(5):526-38.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

SCH 23390 HCl - Bio-X

CAS No:
125941-87-9
Synonyms:
(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-Benzazepin-7-ol hydrochloride(9CI)
Chemical Formula:
Molecular Weight:
324.24
Product Structure
References:
1. Bourne JA (2001). SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev 7(4):399-414.
2. Millan MJ et al (2001). The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl) 156(1):58-62.
3. Cadet JL et al (2010). Dopamine D1 receptors, regulation of gene expression in the brain, and neurodegeneration. CNS Neurol Disord Drug Targets 9(5):526-38.
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