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BA166127
BIO-X

A 1070722

High affinity inhibitor of glycogen synthase kinase GSK-3 with Ki of 0.6 nM. A 1070722 showed favourable characteristics for the penetration across blood brain barrier. A 1070722 was also shown to reduce the phosphorylation of microtubule-associated protein Tau.

Technical Data

CAS No: 1384424-80-9
Synonyms: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Product Code: BA166127
Chemical Formula: C17H13F3N4O2
Molecular Weight: 362.31

References


  • Prabhakaran et al (2017). Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chemical Neuroscience 8(8):1697-1703.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1384424-80-9
Synonyms:
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Chemical Formula:
Molecular Weight:
362.31
Product Structure
References:
1. Prabhakaran et al (2017). Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chemical Neuroscience 8(8):1697-1703.
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