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BB166031
BIO-X

BAY 876 NEW

Selective and potent inhibitor of glucose transporter GLUT1 with IC50 of 2 nM. The compound limits glucose uptake and is able to block basal as well as stress-regulated glycolysis in ovarian cancer cells. It supresses proliferation, viability and tumorigenicity of ovarian cancer cells.

Technical Data

CAS No: 1799753-84-6
Product Code: BB166031
MDL No: MFCD30377201
Chemical Formula: C24H16F4N6O2
Molecular Weight: 496.42

References


  • Siebeneicher H et al (2016). Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem 11(20):2261-2271.
  • Hamilton KE et al (2018). Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie 151:107-114.
  • Ma et al (2019). Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers 11(1):33.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1799753-84-6
MDL No:
MFCD30377201
Chemical Formula:
Molecular Weight:
496.42
Product Structure
References:
1. Siebeneicher H et al (2016). Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem 11(20):2261-2271.
2. Hamilton KE et al (2018). Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie 151:107-114.
3. Ma et al (2019). Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers 11(1):33.
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