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BB166031

BAY 876 - Bio-X

Selective antagonist of the facilitative glucose transporter GLUT1 (IC50 = 2 nM), with 150- to 5000-fold lower IC50s for other GLUTs (GLUT2, GLUT3 and GLU4). GLUTs are often overexpressed in tumors, to meet the increased demand, and are therefore anti-cancer therapeutic targets.

Technical Data

CAS No: 1799753-84-6
Product Code: BB166031
Chemical Formula: C24H16F4N6O2
Molecular Weight: 496.42

References


  • Siebeneicher H et al (2016). Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem 11(20):2261-2271.
  • Hamilton KE et al (2018). Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie 151:107-114.

Solubility

Stability

Further Information


Datasheets


BAY 876 - Bio-X

CAS No:
1799753-84-6
Chemical Formula:
Molecular Weight:
496.42
Product Structure
References:
1. Siebeneicher H et al (2016). Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem 11(20):2261-2271.
2. Hamilton KE et al (2018). Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1. Biochimie 151:107-114.

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