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AA08264

Aclacinomycin A

Dual inhibitor of topoisomerase I and II

Technical Data

CAS No: 57576-44-0
Synonyms: Aclarubicin
Product Code: AA08264
MDL No: MFCD00866250
Chemical Formula: C42H53NO15
Molecular Weight: 811.87

Literature


  • Figueirodo-Pereira ME, et.al (1996). The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome. J Biol Chem 271: 16455.
  • Hajji N et al (2005). Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res 583(1):26-35.
  • Rogalska A et al (2010). Aclarubicin-induced apoptosis and necrosis in cells derived from human solid tumours. Mutat Res 700(1-2):1-10.

Solubility

Stability

Further Information


Datasheets

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Aclacinomycin A

CAS No:
57576-44-0
Synonyms:
Aclarubicin
MDL No:
MFCD00866250
Chemical Formula:
Molecular Weight:
811.87
Product Structure
References:
1. Figueirodo-Pereira ME, et.al (1996). The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome. J Biol Chem 271: 16455.
2. Hajji N et al (2005). Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res 583(1):26-35.
3. Rogalska A et al (2010). Aclarubicin-induced apoptosis and necrosis in cells derived from human solid tumours. Mutat Res 700(1-2):1-10.
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