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BV164560

Vorinostat

Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It targets histones and non-histone proteins within transcription factor complexes involved in regulation of cell proliferation (p53), protein stability (Hsp90), apoptosis (Bcl-2 family), cell motility (α-tublin), and angiogenesis (HIF-1α). Vorinostat affects epigenetic regulation in various cancers and has been used in clinical trials as anticancer drug.

Technical Data

CAS No: 149647-78-9
Synonyms: N-Hydroxy-N'-phenyl-octanediamide; Suberoylanilide hydroxamic acid; SAHA
Product Code: BV164560
MDL No: MFCD00945317
Chemical Formula: C14H20N2O3
Molecular Weight: 264.32

References


  • Lee, J and R, SH (2013). Cancer Epigenetics: Mechanisms and Crosstalk of a HDAC Inhibitor, Vorinostat. Chemotherapy 2(111): 14934.
  • Bubna, AK (2015). Vorinostat—An Overview. Indian Journal of Dermatology 60(4): 419.

Solubility

Stability

Further Information


Datasheets


Vorinostat

CAS No:
149647-78-9
Synonyms:
N-Hydroxy-N'-phenyl-octanediamide
Suberoylanilide hydroxamic acid
SAHA
MDL No:
MFCD00945317
Chemical Formula:
Molecular Weight:
264.32
Product Structure
References:
1. Lee, J and R, SH (2013). Cancer Epigenetics: Mechanisms and Crosstalk of a HDAC Inhibitor, Vorinostat. Chemotherapy 2(111): 14934.
2. Bubna, AK (2015). Vorinostat—An Overview. Indian Journal of Dermatology 60(4): 419.

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