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BY162499
BIO-X

Y 27632 dihydrochloride

Specific inhibitor of Rho-associated ROCK kinases which supresses tumour cell invasion and affects cell proliferation, differentiation and motility. The compound competes with ATP for binding to the kinase catalytic site and inhibits phosphorylation of ROCK substrates. This inhibitor was also shown to attenuate neuronal death after transient retinal ischemia and to possess protective effects on human embryonic stem cells.

Technical Data

CAS No: 129830-38-2
Synonyms: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide dihydrochloride monohydrate
Product Code: BY162499
MDL No: MFCD06245589
Chemical Formula: C14H21N3O·2HCl
Molecular Weight: 320.26

References


  • Ishizaki et al (2000). Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases. Molecular Pharmacology 57(5):976-983.
  • Imamura et al (2005). Y‐27632, an Inhibitor of Rho‐associated Protein Kinase, Suppresses Tumor Cell Invasion via Regulation of Focal Adhesion and Focal Adhesion Kinase. Cancer Science 91(8):811-816.
  • Amano et al (2010). Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity. Cytoskeleton Hoboken 67(9):545-554.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
129830-38-2
Synonyms:
trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide dihydrochloride monohydrate
MDL No:
MFCD06245589
Chemical Formula:
Molecular Weight:
320.26
Product Structure
References:
1. Ishizaki et al (2000). Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases. Molecular Pharmacology 57(5):976-983.
2. Imamura et al (2005). Y‐27632, an Inhibitor of Rho‐associated Protein Kinase, Suppresses Tumor Cell Invasion via Regulation of Focal Adhesion and Focal Adhesion Kinase. Cancer Science 91(8):811-816.
3. Amano et al (2010). Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity. Cytoskeleton Hoboken 67(9):545-554.
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