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FA01480

Alloxane

A pyrimidine derivative, widely used for the induction of diabetes in experimental animals. It preferentially accumulates in pancreatic β cells in Langerhans islets via glucose transporter GLUT2. In the presence of intracellular thiols such as glutathione, it gets involved in a cyclic redox reaction with its reduction product, dialuric acid. This triggers the production of toxic levels of reactive oxygen species (ROS) and directs the cells in necrosis. Alloxan also inhibits glucokinase, which regulates glucose-induced insulin secretion.

Technical Data

CAS No: 50-71-5
Product Code: FA01480
MDL No: MFCD00006031
Chemical Formula: C4H2N2O4
Molecular Weight: 142.07

References


  • Lenzen 2008. The mechanisms of alloxan- and streptozotocin-induced Diabetes. Diabetologia 51:216–226.
  • Takasu et al., 1991. Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes 40(9):1141-5.

Solubility

Stability

Further Information


Datasheets


CAS No:
50-71-5
MDL No:
MFCD00006031
Chemical Formula:
Molecular Weight:
142.07
Product Structure
References:
1. Lenzen 2008. The mechanisms of alloxan- and streptozotocin-induced Diabetes. Diabetologia 51:216–226.
2. Takasu et al., 1991. Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Diabetes 40(9):1141-5.

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