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AB46332

Bleomycin A5 HCl - Bio-X

An antibiotic with potent anti-tumor activity exhibited by intercalating with DNA and causing toxic lesions. A polyamine analogue that is imported into cells via the carnitine transporters Agp2 and hCT2. Used in combination with other anti-tumor drugs to treat lymphomas, testicular and squamous cell carcinomas.

Technical Data

CAS No: 55658-47-4
Synonyms: Bleocin
Product Code: AB46332
MDL No: MFCD01740724
Chemical Formula: C57H89CuN19O21S23HCl
Molecular Weight: 1613.49

Literature


  • Aouida M and Ramotar (2010). A new twist in cellular resistance to the anticancer drug bleomycin-A5. Curr Drug Metab 11(7):595-602.
  • Aouida M et al (2010). The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem 285(9):6275-84.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

Bleomycin A5 HCl - Bio-X

CAS No:
55658-47-4
Synonyms:
Bleocin
MDL No:
MFCD01740724
Chemical Formula:
Molecular Weight:
1613.49
Product Structure
References:
1. Aouida M and Ramotar (2010). A new twist in cellular resistance to the anticancer drug bleomycin-A5. Curr Drug Metab 11(7):595-602.
2. Aouida M et al (2010). The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem 285(9):6275-84.
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