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BG167285

GNE 131 - Bio-X

A triazole sulphonamide that selectively inhibits sodium channel NaV1.7, by binding to the VSD4 site. GNE 131 demonstrated high potency and metabolic stability in vitro. NaV1.7 is a potential target for the treatment of pain, due to its role in nociception. It has high efficacy in transgenic mouse model of induced pain. 

Technical Data

CAS No: 1629063-81-5
Product Code: BG167285
Chemical Formula: C23H30N4O3S
Molecular Weight: 442.58

References


  • Focken T et al (2018). Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem 61(11):4810-4831.

Solubility

Stability

Further Information


Datasheets


GNE 131 - Bio-X

CAS No:
1629063-81-5
Chemical Formula:
Molecular Weight:
442.58
Product Structure
References:
1. Focken T et al (2018). Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain. J Med Chem 61(11):4810-4831.

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