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BL161518

Larotrectinib sulphate - Bio-X

A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.

Technical Data

CAS No: 1223405-08-0
Synonyms: LOXO 101 sulfate
Product Code: BL161518
Chemical Formula: C21H22F2N6O2H2SO4
Molecular Weight: 526.51

References


  • Vaishnavi A et al (2013). Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med 19(11):1469-1472.
  • Doebele RC et al (2015). An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov 5(10):1049-57.
  • Landman Y et al (2018). Rapid Response to Larotrectinib (LOXO-101) in an Adult Chemotherapy-Naive Patients With Advanced Triple-Negative Secretory Breast Cancer Expressing ETV6-NTRK3 Fusion. Clin Breast Cancer 18(3):e267-e270.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

Larotrectinib sulphate - Bio-X

CAS No:
1223405-08-0
Synonyms:
LOXO 101 sulfate
Chemical Formula:
Molecular Weight:
526.51
Product Structure
References:
1. Vaishnavi A et al (2013). Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med 19(11):1469-1472.
2. Doebele RC et al (2015). An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov 5(10):1049-57.
3. Landman Y et al (2018). Rapid Response to Larotrectinib (LOXO-101) in an Adult Chemotherapy-Naive Patients With Advanced Triple-Negative Secretory Breast Cancer Expressing ETV6-NTRK3 Fusion. Clin Breast Cancer 18(3):e267-e270.
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