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BD162772

DMH-1 - Bio-X

A specific inhibitor of Bone Morphogenetic Protein (BMP) type 1 receptors ALK2 and ALK3 (IC50  < 0.5 µM). Dorsomorphin analog that exclusively targets the BMP but not VEGF signaling. It is able to inhibit the BMP-induced Smad1/5/8 activation but not the p38/MAP kinase signaling or Activin A-induced Smad2 activation.

Technical Data

CAS No: 1206711-16-1
Synonyms: 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Product Code: BD162772
Chemical Formula: C24H20N4O
Molecular Weight: 380.44

References


  • Hao J et al., (2010). In Vivo Structure Activity Relationship Study of Dorsomorphin Analogs Identifies Selective VEGF and BMP Inhibitors. ACS Chem Biol 5(2): 245–253.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

DMH-1 - Bio-X

CAS No:
1206711-16-1
Synonyms:
4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Chemical Formula:
Molecular Weight:
380.44
Product Structure
References:
1. Hao J et al., (2010). In Vivo Structure Activity Relationship Study of Dorsomorphin Analogs Identifies Selective VEGF and BMP Inhibitors. ACS Chem Biol 5(2): 245–253.
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