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BS167479
BIO-X

SynuClean D

Inhibits aggregation of α-synuclein by binding to the inner cavity of α-synuclein fibrils. α-synuclein is a major component of amyloid deposition in dopaminergic neurons of Parkinson’s patients. SynuCleanD has therapeutic potential in Parkinson’s disease as it can prevent the degeneration of dopaminergic neurons.

Technical Data

CAS No: 685121-45-3
Synonyms: SynuClean-D; SC-D; 1,​2-​dihydro-​5-​nitro-​6-​(3-​nitrophenyl)​-​2-​oxo-​4-​(trifluoromethyl)​-3-​Pyridinecarbonitrile​
Product Code: BS167479
MDL No: MFCD31735118
Chemical Formula: C13H5F3N4O5
Molecular Weight: 354.20

References


  • Pujols J et al (2018). Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A 115(41):10481-10486.

Solubility

Stability

Further Information


Datasheets


CAS No:
685121-45-3
Synonyms:
SynuClean-D
SC-D
1,​2-​dihydro-​5-​nitro-​6-​(3-​nitrophenyl)​-​2-​oxo-​4-​(trifluoromethyl)​-3-​Pyridinecarbonitrile​
MDL No:
MFCD31735118
Chemical Formula:
Molecular Weight:
354.20
Product Structure
References:
1. Pujols J et al (2018). Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A 115(41):10481-10486.

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