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BW162077

WAY 100635 maleate NEW

This compound is a standard serotonin receptor 5-HT1A antagonist with IC50  = 8.8 nM. In rodents, WAY 100635 itself induced no overt behavioural changes. However, it blocked the 8-OH-DPAT-induced hypothermia and behavioural syndrome. Furthermore, the compound causes malformations of the central nervous system in ascidian embryos.

Technical Data

CAS No: 634908-75-1
Synonyms: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide; Rec 0/0277
Product Code: BW162077
Chemical Formula: C25H34N4O2·xC4H4O4
Molecular Weight: 538.64

Literature

References
  • Forster et al., 1995. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 281(1):81-8.
  • Pennati et al., 2003. WAY-100635, an antagonist of 5-HT1A receptor, causes malformations of the CNS in ascidian embryos. Dev Genes and Evolut. 213, 4, pp187–192.

Solubility

Stability

Datasheets


WAY 100635 maleate

CAS No:
634908-75-1
Synonyms:
N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide
Rec 0/0277
Chemical Formula:
Molecular Weight:
538.64
Product Structure
References:
1. Forster et al., 1995. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur J Pharmacol. 281(1):81-8.
2. Pennati et al., 2003. WAY-100635, an antagonist of 5-HT1A receptor, causes malformations of the CNS in ascidian embryos. Dev Genes and Evolut. 213, 4, pp187–192.

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