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BB168136
BIO-X

BAY 8002 NEW

Inhibitor of lactate uptake and efflux via monocarboxylate transporter MCT1. The blockade of lactate transport with BAY 8002 leads to accumulation of lactate and pyruvate in cells. The MCT1 inhibition decreased tumour growth most effectively in diffuse large B-cell lymphoma cell lines and in subsets of solid tumour models.

Technical Data

CAS No: 724440-27-1
Synonyms: 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
Product Code: BB168136
Chemical Formula: C20H14ClNO5S
Molecular Weight: 415.85

References


  • Quanz et al (2018). Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Molecular Cancer Therapeutics 17(11):2285-2296.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
724440-27-1
Synonyms:
2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
Chemical Formula:
Molecular Weight:
415.85
Product Structure
References:
1. Quanz et al (2018). Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance. Molecular Cancer Therapeutics 17(11):2285-2296.
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