Availability
0
Your Basket is Empty
BN165240
BIO-X

NAcM-OPT NEW

Inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.

Technical Data

CAS No: 2089293-61-6
Product Code: BN165240
Chemical Formula: C23H29Cl2N3O
Molecular Weight: 434.40

References


  • Scott DC et al (2011). N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science 334(6056):674-8.
  • Scott et al (2017). Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase. Nat Chem Biol 13(8): 850–857.
  • Hammill JT et al (2018). Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61(7):2694-2706.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

NAcM-OPT - Bio-X

CAS No:
2089293-61-6
Chemical Formula:
Molecular Weight:
434.40
Product Structure
References:
1. Scott DC et al (2011). N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science 334(6056):674-8.
2. Scott et al (2017). Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase. Nat Chem Biol 13(8): 850–857.
3. Hammill JT et al (2018). Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61(7):2694-2706.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...