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BK43330
BIO-X

KU 55933 NEW

Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase. 

Technical Data

CAS No: 587871-26-9
Synonyms: 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
Product Code: BK43330
MDL No: MFCD08276985
Chemical Formula: C21H17NO3S2
Molecular Weight: 395.50

References


  • Nadkarni et al., 2012. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol 110(3):349-57.
  • Li and Yang, 2010. The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt. Mol Cancer Ther 9(1):113-25.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
587871-26-9
Synonyms:
2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one
MDL No:
MFCD08276985
Chemical Formula:
Molecular Weight:
395.50
Product Structure
References:
1. Nadkarni et al., 2012. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol 110(3):349-57.
2. Li and Yang, 2010. The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt. Mol Cancer Ther 9(1):113-25.
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