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BD162804
BIO-X

DG 172 hydrochloride

Potent inverse agonist of peroxisome proliferator-activated receptor PPARβ and PPARδ with IC50 value of 27 nM. In mouse myoblasts, DG 172 enhanced recruitment of transcriptional corepressor and down-regulated transcription of PPARβ/δ target gene Angptl4. DG 172 also possess a PPARβ/δ-independent activity on bone marrow cells and promotes dendritic cell differentiation.

Technical Data

CAS No: 1361504-77-9
Synonyms: (alphaZ)-2-Bromo-alpha-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile monohydrochloride
Product Code: BD162804
MDL No: MFCD29924728
Chemical Formula: C20H20BrN3·HCl
Molecular Weight: 418.76

References


  • Lieber et al (2012). (Z)-2-(2-Bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An Orally Bioavailable PPARβ/δ-Selective Ligand with Inverse Agonistic Properties. Journal of Medicinal Chemistry 55(6):2858-2868.
  • Lieber et al (2014). The Inverse Agonist DG172 Triggers a PPARb/d-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation. Molecular Pharmacology 87:162–173.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1361504-77-9
Synonyms:
(alphaZ)-2-Bromo-alpha-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile monohydrochloride
MDL No:
MFCD29924728
Chemical Formula:
Molecular Weight:
418.76
Product Structure
References:
1. Lieber et al (2012). (Z)-2-(2-Bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An Orally Bioavailable PPARβ/δ-Selective Ligand with Inverse Agonistic Properties. Journal of Medicinal Chemistry 55(6):2858-2868.
2. Lieber et al (2014). The Inverse Agonist DG172 Triggers a PPARb/d-Independent Myeloid Lineage Shift and Promotes GM-CSF/IL-4-Induced Dendritic Cell Differentiation. Molecular Pharmacology 87:162–173.
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