Availability
0
Your Basket is Empty
BG168492
BIO-X

Yoda 1

Agonist of mechanosensitive cation channel Piezo1, which is expressed in bladder, kidney, lung, colon and skin tissues. Yoda 1 stabilizes the Piezo1 channel in an open state and reduces the threshold for mechanical activation. Yoda 1 also partially activates the Piezo1 channel in absence of mechanical stimuli.

Technical Data

CAS No: 448947-81-7
Synonyms: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Product Code: BG168492
Chemical Formula: C13H8Cl2N4S2
Molecular Weight: 355.27

References


  • Mikhailov et al (2019). Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine? Neuropharmacology 149:113-123.
  • Lacroix et al (2018). Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nature Communications 9:2029.
  • Syeda et al (2015). Chemical activation of the mechanotransduction channel Piezo1. ELife:e07369.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
448947-81-7
Synonyms:
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
Chemical Formula:
Molecular Weight:
355.27
Product Structure
References:
1. Mikhailov et al (2019). Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine? Neuropharmacology 149:113-123.
2. Lacroix et al (2018). Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1. Nature Communications 9:2029.
3. Syeda et al (2015). Chemical activation of the mechanotransduction channel Piezo1. ELife:e07369.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...