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BG166671

GSK 4027 - Bio-X

Selective inhibitor of lysine acetyl transferases 2A and 2B bromodomains (KAT2A and KAT2B). KAT2A is also known as General Control Nonderepressible 5 (GCN5) and has high homology with C-terminal domain of KAT2B bromodomain, known as p300/CBP-Associated Factor (PCAF). The compound is cell penetrant and has over 18000-fold selectivity over the bromodomain and extra terminal (BET) family.

Technical Data

CAS No: 2079896-25-4
Product Code: BG166671
Chemical Formula: C17H21BrN4O
Molecular Weight: 377.28

Literature


  • Humphreys PG et al (2017). Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J. Med. Chem 60(2):695-709.

Solubility

Stability

Further Information


Datasheets


GSK 4027 - Bio-X

CAS No:
2079896-25-4
Chemical Formula:
Molecular Weight:
377.28
Product Structure
References:
1. Humphreys PG et al (2017). Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J. Med. Chem 60(2):695-709.

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