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BR166508
BIO-X

RCM 1 NEW

Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.

Technical Data

CAS No: 339163-65-4
Synonyms: 2-[2-oxo-2-(2-thienyl)ethyl]sulfanyl-4,6-bis(2-thienyl)pyridine-3-carbonitrile
Product Code: BR166508
Chemical Formula: C20H12N2OS4
Molecular Weight: 424.59

References


  • Sun et al., 2017. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Science Signaling 10(475).

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

RCM 1 - Bio-X

CAS No:
339163-65-4
Synonyms:
2-[2-oxo-2-(2-thienyl)ethyl]sulfanyl-4,6-bis(2-thienyl)pyridine-3-carbonitrile
Chemical Formula:
Molecular Weight:
424.59
Product Structure
References:
1. Sun et al., 2017. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Science Signaling 10(475).
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