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OO46228

GM2-Oligosaccharide

Oligosaccharide domain of the monosialylated glycosphingolipid GM2 of a-series. The compound is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system. GM2 is also overexpressed in melanomas and other tumours of neuro-ecto origin. Moreover, the sugar moiety of this ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus.

Technical Data

Product Code: OO46228
Chemical Formula: C31H51N2O24Na
Molecular Weight: 858.73

References


  • Walkley et al (2006). GM2 Ganglioside as a Regulator of Pyramidal Neuron Dendritogenesis. Annals of the New York Academy of Sciences 845:188-99.
  • Martinez et al (2013). Gangliosides have a functional role during rotavirus cell entry. Journal of Virology 87:1115–1122.
  • Stencel-Baerenwald et al (2015). Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. MBio 6(2):e02356.
  • Huang et al (1997). Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases. Human Molecular Genetics 6(11):1879-1885.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

Chemical Formula:
Molecular Weight:
858.73
Product Structure
References:
1. Walkley et al (2006). GM2 Ganglioside as a Regulator of Pyramidal Neuron Dendritogenesis. Annals of the New York Academy of Sciences 845:188-99.
2. Martinez et al (2013). Gangliosides have a functional role during rotavirus cell entry. Journal of Virology 87:1115–1122.
3. Stencel-Baerenwald et al (2015). Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. MBio 6(2):e02356.
4. Huang et al (1997). Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases. Human Molecular Genetics 6(11):1879-1885.
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