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FD05800

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl

Water soluble reagent; carboxyl activating agent; used in immunoconjugates

Technical Data

CAS No: 25952-53-8
Synonyms: EDC.HCl; EDAC.HCl; Water Soluble Carbodiimide; N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide HCl; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl
Product Code: FD05800
MDL No: MFCD00012503
Chemical Formula: C8H17N3HCl
Molecular Weight: 191.7

Literature


  • Atwal et al (1989). A facile synthesis of cyanoguanidines from thioureas. Tetrahedron Letters 30(52):7313-7316., Robl JA et al (1997). Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40(11):1570-7.
  • Dhaon et al (1982). Esterification of N-protected .alpha.-amino acids with alcohol/carbodiimide/4-(dimethylamino)pyridine. Racemization of aspartic and glutamic acid derivatives. J Org Chem 47:1962., Robl JA et al (1997). Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40(11):1570-7.
  • Hagiwara D et al (1994). Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds. J Med Chem 37(13):2090-9.
  • Liang G-B and Feng DD (1996). An improved oxadiazole synthesis using peptide coupling reagents. Tetrahedron Letters 37, 6627.
  • Millan KM and Mikkelsen SR (1993). Sequence-selective biosensor for DNA based on electroactive hybridization indicators. Anal Chem 65(17):2317-2323.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View
Technical Bulletin: View

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide HCl

CAS No:
25952-53-8
Synonyms:
EDC.HCl
EDAC.HCl
Water Soluble Carbodiimide
N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide HCl
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl
MDL No:
MFCD00012503
Chemical Formula:
Molecular Weight:
191.7
Product Structure
References:
1. Atwal et al (1989). A facile synthesis of cyanoguanidines from thioureas. Tetrahedron Letters 30(52):7313-7316., Robl JA et al (1997). Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40(11):1570-7.
2. Dhaon et al (1982). Esterification of N-protected .alpha.-amino acids with alcohol/carbodiimide/4-(dimethylamino)pyridine. Racemization of aspartic and glutamic acid derivatives. J Org Chem 47:1962., Robl JA et al (1997). Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase. J Med Chem 40(11):1570-7.
3. Hagiwara D et al (1994). Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds. J Med Chem 37(13):2090-9.
4. Liang G-B and Feng DD (1996). An improved oxadiazole synthesis using peptide coupling reagents. Tetrahedron Letters 37, 6627.
5. Millan KM and Mikkelsen SR (1993). Sequence-selective biosensor for DNA based on electroactive hybridization indicators. Anal Chem 65(17):2317-2323.
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