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BA164085
BIO-X

A196

Selective inhibitor histone methyltransferases SUV420H1 and SUV420H2 (IC50 values = 25 nM and 144 nM, respectively). Reduces histone H4K20me2 and H4K20me3 expression whilst increasing H4K20me1 global expression. Inhibits formation of p53-binding protein 1 (53BP1) foci upon ionizing radiation and reduces NHEJ-mediated DNA-break repair.

Technical Data

CAS No: 1982372-88-2
Synonyms: 6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Product Code: BA164085
Chemical Formula: C18H16Cl2N4
Molecular Weight: 359.25

Literature

References
  • Bromberg KD et al (2017). The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol 13(3):317-324.

Solubility

Stability

Datasheets

MSDS: View

A196 - Bio-X

CAS No:
1982372-88-2
Synonyms:
6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Chemical Formula:
Molecular Weight:
359.25
Product Structure
References:
1. Bromberg KD et al (2017). The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol 13(3):317-324.
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