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FA30834

Arimoclomol - Bio-X NEW

A co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.

Technical Data

CAS No: 289893-25-0
Synonyms: (R)-N-[2-Hydroxy-3-(1-piperidinyl)-propoxy]-3-pyridinecarboximidoyl chloride 1-oxide
Product Code: FA30834
Chemical Formula: C14H20ClN3O3
Molecular Weight: 313.78

Literature


  • Kalmar B et al (2014). The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol. Pharmacol Ther 141(1):40-54.
  • Deane CA and Brown IR (2016). Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol. Cell Stress Chaperones 21(5):837-48.
  • Kirkegaard T et al (2016). Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses. Sci Transl Med 8(355):355ra118.

Solubility

Stability

Further Information


Datasheets

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Arimoclomol - Bio-X

CAS No:
289893-25-0
Synonyms:
(R)-N-[2-Hydroxy-3-(1-piperidinyl)-propoxy]-3-pyridinecarboximidoyl chloride 1-oxide
Chemical Formula:
Molecular Weight:
313.78
Product Structure
References:
1. Kalmar B et al (2014). The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol. Pharmacol Ther 141(1):40-54.
2. Deane CA and Brown IR (2016). Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol. Cell Stress Chaperones 21(5):837-48.
3. Kirkegaard T et al (2016). Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses. Sci Transl Med 8(355):355ra118.
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