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OG31354

GM1-Ganglioside labelled by biotin

Monosialylated glycosphingolipid and a major ganglioside in neuronal and glial membranes in the central nervous system. GM1 ganglioside interacts and modulates tyrosine kinases such as neural tropomyosin receptor kinase A (TrkA) and the epidermal growth factor receptor (EGFR). The compound is also found in epithelial membranes and is a key element for bacterial toxicity and viral infection since it acts as a receptor for the B-subunits of heat labile toxin, cholera toxin, rotavirus, and simian virus 40. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis.

Technical Data

Synonyms: N-Hexanoyl-biotin-monosialoganglioside GM1
Product Code: OG31354
Chemical Formula: C71H122N6O33S
Molecular Weight: 1619.82

References


  • Rabin and Mocchetti (1995). GM1 ganglioside activates the high-affinity nerve growth factor receptor TrkA. Journal of Neurochemistry 65:347–354.
  • Coskun et al (2011). Regulation of human EGF receptor by lipids. PNAS 108:9044–9048.
  • Jobling and Holmes (2002). Mutational analysis of ganglioside GM1-binding ability, pentamer formation, and epitopes of cholera toxin B (CTB) subunits and CTB/heat-labile enterotoxin B subunit chimeras. Infection and Immunity 70:1260–1271.
  • Yu et al (2011). Novel structural insights into rotavirus recognition of ganglioside glycan receptors. Journal of Molecular Biology 413:929–939.
  • Yanagisawa (2005). GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloid. Neuroscientist 11(3):250-60.

Solubility

Stability

Further Information


Datasheets


Synonyms:
N-Hexanoyl-biotin-monosialoganglioside GM1
Chemical Formula:
Molecular Weight:
1619.82
Product Structure
References:
1. Rabin and Mocchetti (1995). GM1 ganglioside activates the high-affinity nerve growth factor receptor TrkA. Journal of Neurochemistry 65:347–354.
2. Coskun et al (2011). Regulation of human EGF receptor by lipids. PNAS 108:9044–9048.
3. Jobling and Holmes (2002). Mutational analysis of ganglioside GM1-binding ability, pentamer formation, and epitopes of cholera toxin B (CTB) subunits and CTB/heat-labile enterotoxin B subunit chimeras. Infection and Immunity 70:1260–1271.
4. Yu et al (2011). Novel structural insights into rotavirus recognition of ganglioside glycan receptors. Journal of Molecular Biology 413:929–939.
5. Yanagisawa (2005). GM1 ganglioside and the seeding of amyloid in Alzheimer's disease: endogenous seed for Alzheimer amyloid. Neuroscientist 11(3):250-60.

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