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BP34124
BIO-X

PD 98059 NEW

MAP kinase kinase (MEK) inhibitor. Binds to MEK-1, preventing phosphorylation and activation by Raf or MEK kinase. PD 098059 enhances self-renewal in stem cells. Has anti-growth and anti-proliferative effects on AML cells. Anti-apoptotic effect on AML cells observed in synergy with Nutlin-3a.

Technical Data

CAS No: 167869-21-8
Synonyms: 2-(2-Amino-3-methoxyphenyl)-4H-chromen-4-one
Product Code: BP34124
MDL No: MFCD00671789
Chemical Formula: C16H13O3N
Molecular Weight: 267.28

Literature

References
  • Alessi DR et al (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270(46):27489-94.
  • Qi X et al (2004). BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 101(16):6027-32.
  • Kojima et al (2007). Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. Cancer Res 67(7):3210-9

Solubility

Stability

Datasheets

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PD 98059 - Bio-X

CAS No:
167869-21-8
Synonyms:
2-(2-Amino-3-methoxyphenyl)-4H-chromen-4-one
MDL No:
MFCD00671789
Chemical Formula:
Molecular Weight:
267.28
Product Structure
References:
1. Alessi DR et al (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270(46):27489-94.
2. Qi X et al (2004). BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc Natl Acad Sci U S A 101(16):6027-32.
3. Kojima et al (2007). Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. Cancer Res 67(7):3210-9
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